What are enteric-coated capsules and what are their functions?

Enteric-coated capsules are a type of drug formulation that undergoes special processing. The coating does not dissolve in the acidic environment of the stomach (low pH), and only disintegrates and releases the drug when it reaches the intestine (with a more neutral or weakly alkaline pH). They effectively prevent the drug from irritating the stomach, prevent the destruction of the drug's activity by stomach acid, and improve the efficiency of absorption in the intestine. When using them, it is essential to swallow the entire capsule without chewing, crushing, splitting or grinding. It is usually recommended to take them on an empty stomach before meals.
Key points:
Design principle: Using acid-resistant capsule shells or coating materials to keep the drug intact in the stomach and dissolve in the intestine.
Applicable drugs:
Drugs that are irritating to the stomach: such as aspirin, diclofenac sodium.
Drugs that are prone to inactivation in stomach acid: such as certain stomach medications (omeprazole), pancreatic enzymes, etc.
Taking points:
Do not chew: Breaking the coating will cause the drug to release prematurely, lose its efficacy, and potentially severely irritate the stomach.
Take on an empty stomach: Eating can increase the pH value in the stomach, causing the drug to release prematurely. It is recommended to take it 30 minutes before meals with cold water.
Avoid acid-base drugs: It is not advisable to take them simultaneously with antacid drugs (such as aluminum carbonate magnesium) or acid-suppressing drugs (such as cimetidine) as this may affect the enteric-coating effect.